Home » Research » BPC-157, the orally available peptide that repairs tendon, muscle, intestines, teeth, bone and more in vitro & vivo

BPC-157, the orally available peptide that repairs tendon, muscle, intestines, teeth, bone and more in vitro & vivo

What Is BPC-157?

Bpc-157 is, in a word, a peptide.

A peptide is simply a sequence of amino acids.

In the case of BPC-157, the peptide is a sequence of amino acids with a molecular formula of 62 carbons, 98 hydrogens, 16 nitrogens, and 22 oxygen atoms (C62-H98-N16-O22).

Should you care to know the nitty-gritty specifics, that comes out to a fifteen amino acid sequence of the following:

L-Valine, glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-; glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine.

Yep, that’s the long, fancy name for BPC-157.

BPC, for reasons you’re about to discover, stands for “Body Protecting Compound”. Your body already makes it in your own gastric juices in very small amounts, where it serves to protect and heal your gut. But if you can get the super concentrated version and get it into your system, it has an extremely high level of biological healing activity just about anywhere you put it

What Does BPC-157 Do?

BPC-157 is surprisingly free of side effects, and has been shown in research that’s been happening since 1991 to repair tendon, muscle, intestines, teeth, bone and more, both in in-vitro laboratory “test-tube” studies, in in-vivo human and rodent studies, and when used orally or inject subcutaneously (under your skin) or intramuscularly (into your muscle).

Just take a look at the following, all of which was hunted down and identified by the good folks at Suppversity in their article on BPC-157. BPC-157 has been shown to:

  • Promote tendon and ligament healing by tendon outgrowth, cell survival, and cell migration in a rodent model of Achilles tendon rupture, and also when administered in drinking water to rats with damaged medial collateral ligaments
  • Tendon-to-bone healing effective enough that they may actually “successfully exchange the present reconstructive surgical methods”
  • Counter the damaging effects of NSAIDs like ibuprofen or advil on the gut lining so effectively that scientists termed BPC-157 “a NSAIDs antidote” one of which they say that “no other single agent has portrayed a similar array of effects”
  • Repair the damage from inflammatory bowel disease (IBD) within just days of oral administration in a rodent model of IBD
  • Help cure perdidontitis when administered in a rodent model of periodontitis, significantly enough to have scientists conclude that “BPC 157 may represent a new peptide candidate in the treatment of periodontal disease”
  • Reverse systemic corticosteroid-impaired muscle healing, in a rodent models where BPC-157 was administered orally once daily for 14 days to rats with crushed gastrocnemius muscle. Similar benefits were demonstrated in a rodent study by Novinscak et al.
  • Accelerate bone healing in rabbits who suffered segmental bone defect before being treated with BPC-157.
  • BPC-157 is also known as a “stable gastric pentadecapeptide”, primarily because it is stable in human gastric juice, can cause an anabolic healing effect in both the upper and lower GI tract, has an antiulcer effect, and produces a therapeutic effect on inflammatory bowel disease (IBD) – all again surprisingly free of side effects.

As demonstrated in the research studies cited above, BPC-157 also accelerates wound healing, and, via interaction with the Nitric Oxide (NO) system, causes protection of endothelial tissue and an “angiogenic” (blood vessel building) wound healing effect. This occurs even in severely impaired conditions, such as in advanced and poorly controlled irritable bowel disease, in which it stimulates expression of genes responsible for cytokine and growth factor generation and also extracellular matrix (collagen) formation, along with intestinal anastomosis healing, reversal of short bowel syndrome and fistula healing – all of which can extremely frustrating issues in people who have gut pain, constipation, diarrhea and bowel inflammation.

So if you have frustrating joint pain that won’t go away, some kind of muscle tear, sprain or strain, or gut “issues”, you should definitely keep reading.

How To Get BPC-157

You can find BPC-157 at a few different peptide suppliers on the internet. I’ll warn you: kind of like online pharmacies, the websites are cheesy, and they technically aren’t allowed to sell or advertise these kind of peptides as something appropriate for human consumption or human injection, but you can pretty easily find it and buy it if you know how to use your Googling skills properly.

How Much BPC-157 To Take

There is an abundance of research on BPC-157 and it has been shown to be effective systematically when injected once daily at anywhere from 1-10mcg per kg of body weight. In most cases, this comes out to a dose of anywhere from 200mcg up to 800mcg. Some folks report the most success dosing twice per day with 250-350mcg for a total of 500-700mcg per day.

How Long To Take BPC-157

Based on the current human studies to date, BPC-157 can be safely administered for four weeks, followed by a two week rest. Speaking from my own personal experience, in which pain subsided after no more than two weeks of injections, I wouldn’t imagine you’d need to repeat this cycle unless you re-injured yourself.

Summary

OK, so you may be now wondering why in the heck your physician, physical therapist, surgeon, gastroenterologist, etc. hasn’t told you about this stuff.

Here’s the deal: since BPC-157 is a completely natural gastric juice peptides, it’s technically not patentable, period. That means big pharma can’t make money off BPC-157, and that means it’s not getting marketed to your local doctor or hospital or anywhere else in the health care system. It’s also not available as an FDA regulated drug, or even considered to be “sellable” for human use.

You may also be wondering if it’s legal for sports governed by bodies such as USADA or WADA.

Here’s the deal: although some “peptide hormones, growth factors, related substances and mimetics” are indeed illegal for use in sports governed by these organization, BPC-157 is not currently listed as one of those illegal compounds. Yet.

I’ll readily admit that when it comes to BPC-157, despite it being a peptide you can actually find in your own gastric juices, long term studies in humans are relatively sparse. It may also eventually be banned by sport governing bodies such as USADA and WADA.

References:

  • Brcic, L., et al. “Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.” J Physiol Pharmacol 60.Suppl 7 (2009): 191-196.
  • Cerovecki, Tomislav, et al. “Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat.” Journal of orthopaedic research 28.9 (2010): 1155-1161.
  • Chang, Chung-Hsun, et al. “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.” Journal of Applied Physiology 110.3 (2011): 774-780.
  • Chang, Chung-Hsun, et al. “Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.” Molecules 19.11 (2014): 19066-19077.
  • Keremi, B., et al. “Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.” Journal of physiology and pharmacology 60.7 (2009): 115-122.
  • Krivic, Andrija, et al. “Achilles Detachment in Rat and Stable Gastric Pentadecapeptide BPC 157: Promoted Tendon‐to‐Bone Healing and Opposed Corticosteroid Aggravation.” Journal of orthopaedic research 24.5 (2006): 982-989.
  • Novinscak, Tomislav, et al. “Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.” Surgery today 38.8 (2008): 716-725.
  • Pevec, Danira, et al. “Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application.” Medical Science Monitor 16.3 (2010): BR81-BR88.
  • Šebečić, Božidar, et al. “Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation.” Bone 24.3 (1999): 195-202.
  • Sikirić, Predrag, et al. “A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC.” Journal of Physiology-Paris 87.5 (1993): 313-327.
  • Sikiric, Predrag, et al. “The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H 2 receptor antagonists, dopamine promotors and gut peptides.” Life sciences 54.5 (1994): PL63-PL68.
  • Sikiric, Predrag, et al. “Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157.” Current pharmaceutical design 19.1 (2013): 76-83.
  • Vuksic, Tihomir, et al. “Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.” Surgery today 37.9 (2007): 768-777.

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